Psilocybin retreats in Colorado are legal in 2025 under the framework created by the Natural Medicine Health Act (NMHA), which voters approved in November 2022. The act allows adults 21 and older to use psilocybin in supervised settings and directs the state to license healing centers where guided sessions may take place. While the program is still rolling out, retreat-style experiences are becoming available through regulated channels.
Current Legal Status of Psilocybin in Colorado
Colorado law permits personal use, possession, and sharing of psilocybin for adults over 21. Licensed psilocybin services are being developed under state regulation with the first healing centers expected to be operational by 2025.
Key points of the law include:
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Adults 21 and older may legally use psilocybin in private or supervised settings
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Psilocybin services must be provided in state-approved healing centers
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Licensed facilitators are required to supervise administration sessions
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Growing psilocybin mushrooms for personal use is decriminalized in limited amounts
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Psilocybin remains illegal under federal law, which means it cannot be transported across state lines
How Colorado’s Psilocybin Program Works
Natural Medicine Health Act Framework
The NMHA established the Natural Medicine Division within the Colorado Department of Regulatory Agencies. This division oversees facilitator training, licensing of healing centers, and rulemaking for psilocybin services.
Healing Centers
Psilocybin retreats in Colorado take place in licensed healing centers. These centers are designed to provide safe environments where participants can take psilocybin with facilitator support.
Service Process
Similar to Oregon’s model, Colorado retreats follow three main steps:
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Preparation session: Participants meet with a facilitator to discuss goals and medical history
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Administration session: Psilocybin is consumed under supervision at a healing center
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Integration session: A follow-up meeting helps participants reflect on their experience
Retreat Experience in Colorado
Program Length and Design
Most Colorado psilocybin retreats in 2025 are designed as single-day or multi-day programs depending on the center. Some focus on individual sessions while others provide group formats. All programs must comply with state rules for safety and supervision.
Cost and Accessibility
Pricing is expected to range from several hundred dollars for a single guided session to several thousand for extended retreat-style programs. The cost reflects facilitator certification, facility operations, and compliance with state regulations.
Colorado residents and out-of-state visitors may attend retreats, but psilocybin cannot be taken home or used outside of licensed centers.
Medical and Research Perspectives
While Colorado’s psilocybin program is not classified as medical treatment, researchers are tracking its outcomes. Clinical trials elsewhere in the United States continue to study psilocybin for depression, anxiety, and substance use disorders. Colorado’s regulated retreat system offers valuable real-world data on safety and participant experiences outside of clinical research.
Considerations for Attending a Psilocybin Retreat in Colorado
Legal Protections
Participants are legally protected under state law when using psilocybin within the NMHA framework. Psilocybin remains federally prohibited, creating limitations on travel and transport.
Safety Standards
Facilitators must complete state-approved training focused on harm reduction, crisis response, and ethical care. Healing centers must provide safe physical environments for participants.
Travel Logistics
Visitors traveling to Colorado for retreats must plan around session scheduling and lodging. Psilocybin cannot leave the healing center, so travel arrangements are focused on before and after sessions rather than during.
Broader Retreat Options
While Colorado offers the second statewide regulated system in the United States, some people consider international retreat settings where psilocybin has different legal protections. These may include multi-day programs with lodging and extended integration support.
We at ONE Retreats in Jamaica provide legal psilocybin retreats supported by local law with guided sessions and integration in a setting designed for extended stays.
The Future of Psilocybin Retreats in Colorado
Colorado’s program will expand over the next few years as more facilitators are trained and additional healing centers open. Several factors will influence its development:
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Licensing pace: The number of facilitators and healing centers is expected to grow through 2025 and 2026
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Local opt-outs: Some counties and municipalities have chosen not to allow psilocybin services, limiting availability in certain regions
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Research outcomes: Colorado’s retreat system may inform national policy debates and medical research efforts
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Federal developments: Any future FDA approvals for psilocybin therapies could reshape how state programs interact with medical practice
Key Takeaways for 2025
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Psilocybin retreats in Colorado are legal under the NMHA
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Adults 21 and older may participate without requiring a medical diagnosis
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Retreats take place in licensed healing centers under facilitator supervision
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Programs follow preparation, administration, and integration stages
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Out-of-state visitors may attend but cannot transport psilocybin outside licensed spaces
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Colorado is the second state after Oregon to launch a regulated psilocybin program
Final Thoughts
Psilocybin retreats in Colorado are now legally available in 2025 under a regulated system that prioritizes trained facilitators and safe environments. While still in the early stages of implementation, the program offers structured access to psilocybin and marks another step in how states are handling psychedelic services. Those interested in attending can find licensed healing centers across Colorado, while some may also look to international destinations for extended retreat formats.
