Psilocybin retreats are not legal in Missouri in 2025. The state has no approved retreat centers or therapeutic service models that allow psilocybin to be administered. However, Missouri has taken steps that place it among the states considering reform, including bills in the legislature that would create psilocybin pilot programs for therapeutic purposes.
Current Legal Status of Psilocybin in Missouri
Psilocybin is a Schedule I controlled substance under Missouri law and under federal law. This means that possession, distribution, and use remain prohibited outside of approved federal research studies. Retreats that involve guided psilocybin sessions are not permitted within the state.
Missouri has not enacted local decriminalization measures on the same scale as cities in Massachusetts or Colorado. While there are grassroots groups advocating for reform, no municipality in Missouri has formally deprioritized enforcement through local resolutions.
Legislative Activity in Missouri
House Bill 869 (2023–2024 session)
One of the most significant legislative efforts was House Bill 869, introduced in 2023. This proposal sought to allow psilocybin-assisted therapy for patients with certain mental health conditions such as PTSD, depression, and substance use disorders. The bill would have created a state-run program authorizing medical professionals to oversee psilocybin sessions. Although the bill gained attention, it did not advance out of committee.
Emerging Support for Pilot Programs
State lawmakers and advocacy groups have discussed future bills modeled on Oregon and Colorado systems. Proposed frameworks would focus on:
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Medical oversight of psilocybin use
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Licensed facilitators to guide sessions
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Access for veterans and patients with treatment-resistant conditions
While these ideas remain at the proposal stage, they indicate growing legislative interest in controlled, therapeutic access to psilocybin.
Federal Influence on Missouri Policy
Two ongoing federal developments play a role in Missouri’s debate:
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FDA clinical trials: Psilocybin continues to move through Phase II and Phase III clinical trials for major depressive disorder and PTSD. Results from these studies are shaping state-level interest in pilot programs.
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State precedents: Oregon and Colorado have begun rolling out legal psilocybin service systems. Missouri legislators are observing these examples to evaluate what frameworks might work in their state.
What Psilocybin Retreats Typically Include
Even though retreats cannot legally operate in Missouri, many people search for information about what such programs look like. Retreats in legal settings abroad often include:
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Preparation sessions where facilitators meet participants, review health histories, and clarify intentions
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Supervised psilocybin experiences guided by trained staff in safe and controlled environments
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Complementary practices such as meditation, journaling, or group sharing circles
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Integration support offered after the session to help participants reflect on and process their experiences
This model is most often found in countries where psilocybin use is legally protected.
Options for Missouri Residents
Because psilocybin retreats are not legal in the state, residents seeking guided psilocybin experiences often travel to international destinations where retreats are lawful.
We at ONE Retreats in Jamaica host legal psilocybin retreats with preparation, guided sessions, and integration support in a safe environment.
Preparing for Retreat Travel
Missouri residents who plan to attend retreats abroad usually take time to prepare in these ways:
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Travel planning: Arranging flights, accommodations, and travel documents
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Health screening: Sharing medical background with facilitators to confirm eligibility
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Setting intentions: Reflecting on personal goals and areas of focus before attending
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Recovery period: Allowing extra time after the retreat to rest before returning to daily routines
This preparation helps participants approach the retreat with clarity and focus.
The Future of Psilocybin in Missouri
While psilocybin retreats are not an option in Missouri in 2025, legislative attention has increased. Several factors could shape future change:
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Pending state bills designed to authorize therapeutic pilot programs
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Public pressure from advocacy groups, particularly around support for veterans
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Federal clinical results showing psilocybin’s safety and efficacy under controlled conditions
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Examples from Oregon and Colorado that may encourage lawmakers to consider regulated retreat-style models in the future
Key Takeaways for 2025
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Psilocybin retreats remain illegal in Missouri
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House Bill 869 and related proposals indicate state interest in therapeutic pilot programs
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No city in Missouri has passed formal decriminalization measures to date
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Residents who want to attend retreats must travel abroad to countries where programs operate legally
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Federal trial outcomes and policies in other states could shape Missouri’s future path
Final Thoughts
Psilocybin retreats are not permitted in Missouri in 2025, but legislative attention suggests that controlled therapeutic use is being considered. The progress of pilot programs in other states and federal clinical trials may influence Missouri’s lawmakers in the years ahead. For now, residents seeking guided psilocybin retreats continue to look to international destinations with established legal systems.
